Warrington Borough Council has issued a notice confirming that Mill Lane, Lymm, will be closed between its junctions with Birchbrook Road and Wet Gate Lane.
The closure will be in place from November 3 to November 5.
United Utilities will be carrying out work to install a new customer connection.
During the closure, access will be managed by the contractor.
A diversion route will be in place via Higher Lane, Church Road, Eagle Brow, The Cross, New Road, Rushgreen Road, and Birchbrook Road, and vice versa.
The council has stated that the closure will only be in effect when the relevant signage is displayed on site.